ResearchSafe

4-AcO-DMT (O-Acetylpsilocin (psilacetin))

Category: Psychedelics. Status: Schedule I (research compound).

A lab-made cousin of psilocybin that the body converts into psilocin, producing very similar mushroom-like effects. Popular in research and harm-reduction discussions as a more stable alternative to mushrooms.

How it works

A prodrug converted to psilocin, which activates serotonin 5-HT2A receptors.

Key facts

  • Molecular weight: 246.31 g/mol
  • Half-life: ~2-3 hours
  • Bioavailability: Oral
  • Storage: Research/reference only.

Dosing overview

  • Typical dose: Varies by individual and setting
  • Frequency: Occasional
  • Duration: Acute effects last 3-6 hours
  • Route: Oral

Protocol notes

  • Taken orally as a measured powder or in solution, giving a mushroom-like experience.
  • Popular with careful self-experimenters because doses are easy to weigh precisely.
  • People treat set and setting (mindset and environment) the same as with mushrooms.

Reported benefits

  • Psilocybin-like experience
  • More stable and easy to measure
  • Studied as a research psychedelic
  • Classic serotonergic profile

Possible side effects

  • Anxiety or fear
  • Nausea
  • Raised heart rate and blood pressure
  • Limited human safety data

Community reviews of 4-AcO-DMT

Rated 4 out of 5 from 2 community reviews by ResearchSafe members.

  • wes149 rated it 4/5 - Quieter head, better evenings after long shifts: The biggest thing for me was how it seemed to take the edge off my head after long Midwest workdays and training sessions. I ran it about 6 weeks, and my evenings felt noticeably more settled. Small caveat, it could just be placebo, but imo it was a solid 4 out of 5.
  • scientist_maya rated it 4/5 - Calm reset for my overcooked brain: I tried 4-AcO-DMT after a brutal stretch at work, one of those weeks where my pharmacist brain was still spinning at 11 pm and my HRV looked offended. Over about 6 weeks, I used it sparingly and it seemed to give me a clean psilocybin-like headspace, just easier to measure than mushrooms, which I appreciated. For me it felt like a reset button with a little edge. The only caveat was the next-day fog if I pushed it too far.

Compare 4-AcO-DMT

Community discussions about 4-AcO-DMT

Research and educational reference only. Not medical advice.