4-AcO-DMT (O-Acetylpsilocin (psilacetin))
A lab-made cousin of psilocybin that the body converts into psilocin, producing very similar mushroom-like effects. Popular in research and harm-reduction discussions as a more stable alternative to mushrooms.
How it works
A prodrug converted to psilocin, which activates serotonin 5-HT2A receptors.
Key facts
- Molecular weight: 246.31 g/mol
- Half-life: ~2-3 hours
- Bioavailability: Oral
- Storage: Research/reference only.
Dosing overview
- Typical dose: Varies by individual and setting
- Frequency: Occasional
- Duration: Acute effects last 3-6 hours
- Route: Oral
Protocol notes
- Taken orally as a measured powder or in solution, giving a mushroom-like experience.
- Popular with careful self-experimenters because doses are easy to weigh precisely.
- People treat set and setting (mindset and environment) the same as with mushrooms.
Reported benefits
- Psilocybin-like experience
- More stable and easy to measure
- Studied as a research psychedelic
- Classic serotonergic profile
Possible side effects
- Anxiety or fear
- Nausea
- Raised heart rate and blood pressure
- Limited human safety data
Compare 4-AcO-DMT
Community discussions about 4-AcO-DMT
- Curiosity about moving into psychedelics for mental wellness research - 0 comments
- how to reconstitute 4-aco-dmt for first try? - 6 comments
- 4-aco-dmt: a more stable psilocybin pro‑drug catching attention - 3 comments
- Ask the community about 4-AcO-DMT
Research and educational reference only. Not medical advice.