Dihexa (Oral) (Dihexa (N-hexanoic-Tyr-Ile-(6) Aminohexanoic Amide))
An extremely potent cognitive enhancer that drives synaptogenesis - the formation of new synaptic connections. Reportedly 10 million times more potent than BDNF for promoting new connections. A favorite in telemedicine nootropic protocols.
How it works
Activates hepatocyte growth factor (HGF) / c-Met receptor system in the brain, triggering dendritic spine formation, synaptogenesis, and neuronal survival. This creates new neural pathways for learning and memory.
Key facts
- Molecular weight: 507.63 Da
- Half-life: ~12 hours
- Bioavailability: ~70% oral, ~60% intranasal
- Storage: Room temperature, dry and sealed.
Dosing overview
- Typical dose: 10-20 mg
- Frequency: Daily or every other day
- Duration: 4-8 weeks cycled
- Route: Oral capsule or sublingual
Protocol notes
- Common use is ~10-20 mg/day, often dissolved in a carrier and taken sublingually or as an oil-based capsule.
- Some dose every other day given the long half-life and unknown long-term profile.
- Effects are subtle and cumulative - it builds new connections over weeks, not hours.
Reported benefits
- Synaptogenesis (new brain connections)
- Dramatic memory enhancement
- Learning acceleration
- Neuroprotection
- Cognitive recovery after injury
Possible side effects
- Headache
- Overstimulation
- Insomnia
- Anxiety at high doses
- Unknown long-term profile
Research
- Dihexa and HGF/c-Met synaptogenesis (2020): Restored cognitive function in Alzheimer models with formation of new stable synaptic connections in hippocampus.
Compare Dihexa (Oral)
Research and educational reference only. Not medical advice.