Dihexa (Oral) (Dihexa (N-hexanoic-Tyr-Ile-(6) Aminohexanoic Amide))
An extremely potent cognitive enhancer that drives synaptogenesis - the formation of new synaptic connections. Reportedly 10 million times more potent than BDNF for promoting new connections. A favorite in telemedicine nootropic protocols.
How it works
Activates hepatocyte growth factor (HGF) / c-Met receptor system in the brain, triggering dendritic spine formation, synaptogenesis, and neuronal survival. This creates new neural pathways for learning and memory.
Key facts
- Molecular weight: 507.63 Da
- Half-life: ~12 hours
- Bioavailability: ~70% oral, ~60% intranasal
- Storage: Room temperature, dry and sealed.
Dosing overview
- Typical dose: 10-20 mg
- Frequency: Daily or every other day
- Duration: 4-8 weeks cycled
- Route: Oral capsule or sublingual
Protocol notes
- Common use is ~10-20 mg/day, often dissolved in a carrier and taken sublingually or as an oil-based capsule.
- Some dose every other day given the long half-life and unknown long-term profile.
- Effects are subtle and cumulative - it builds new connections over weeks, not hours.
Reported benefits
- Synaptogenesis (new brain connections)
- Dramatic memory enhancement
- Learning acceleration
- Neuroprotection
- Cognitive recovery after injury
Possible side effects
- Headache
- Overstimulation
- Insomnia
- Anxiety at high doses
- Unknown long-term profile
Research
- Dihexa and HGF/c-Met synaptogenesis (2020): Restored cognitive function in Alzheimer models with formation of new stable synaptic connections in hippocampus.
Community reviews of Dihexa (Oral)
- protocol_planner rated it 4/5 - Worth adding to the protocol: Dihexa (Oral) has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- compound_curious rated it 5/5 - Genuinely effective after 6 weeks: Been using Dihexa (Oral) for about 6 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- morning_pin_maya rated it 5/5 - Noticed clear benefits within weeks: Added Dihexa (Oral) to my protocol about 2 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- protocol_planner rated it 5/5 - Solid compound with real results: Been using Dihexa (Oral) for about 1 month and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
Compare Dihexa (Oral)
Research and educational reference only. Not medical advice.