Dihexa (Oral) vs Semax
A side-by-side research comparison of Dihexa (Oral) and Semax across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Dihexa (Oral) | Semax |
|---|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6) Aminohexanoic Amide) | Semax (ACTH 4-10 analog) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Activates hepatocyte growth factor (HGF) / c-Met receptor system in the brain, triggering dendritic spine formation, synaptogenesis, and neuronal survival. This creates new neural pathways for learning and memory. | Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity. |
| Molecular weight | 507.63 Da | 813.9 Da |
| Half-life | ~12 hours | 3-5 min (systemic) / extended (intranasal) |
| Bioavailability | ~70% oral, ~60% intranasal | Moderate (intranasal) |
| Typical dose | 10-20 mg | 200-600 mcg per dose |
| Frequency | Daily or every other day | 2-3x daily |
| Route | Oral capsule or sublingual | Intranasal drops/spray |
Dihexa (Oral) reported benefits
- Synaptogenesis (new brain connections)
- Dramatic memory enhancement
- Learning acceleration
- Neuroprotection
- Cognitive recovery after injury
Semax reported benefits
- Enhanced attention/focus
- Memory improvement
- Neuroprotection (stroke)
- BDNF/NGF upregulation
- Improved learning
- Optic nerve support
Related comparisons
Research and educational reference only. Not medical advice.