Dihexa (Oral) vs Selank
A side-by-side research comparison of Dihexa (Oral) and Selank across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Dihexa (Oral) | Selank |
|---|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6) Aminohexanoic Amide) | Selank (TP-7) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Activates hepatocyte growth factor (HGF) / c-Met receptor system in the brain, triggering dendritic spine formation, synaptogenesis, and neuronal survival. This creates new neural pathways for learning and memory. | Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance. |
| Molecular weight | 507.63 Da | 751.9 Da |
| Half-life | ~12 hours | 3-5 min (IV) / 15-30 min (intranasal) |
| Bioavailability | ~70% oral, ~60% intranasal | Moderate (intranasal) |
| Typical dose | 10-20 mg | 250-750 mcg per spray dose |
| Frequency | Daily or every other day | 2-3x daily |
| Route | Oral capsule or sublingual | Intranasal spray |
Dihexa (Oral) reported benefits
- Synaptogenesis (new brain connections)
- Dramatic memory enhancement
- Learning acceleration
- Neuroprotection
- Cognitive recovery after injury
Selank reported benefits
- Anxiolytic without sedation
- Improved memory/learning
- Cognitive flexibility
- Immune modulation
- BDNF upregulation
- No addiction
Related comparisons
Research and educational reference only. Not medical advice.