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Enclomiphene (Enclomiphene Citrate)

Category: Hormone Replacement. Status: Investigational drug.

A selective estrogen receptor modulator (SERM) and the trans-isomer of clomiphene. Widely prescribed by telemedicine clinics as a testosterone optimization therapy that maintains fertility, unlike exogenous testosterone.

How it works

Blocks estrogen receptors in the hypothalamus, reducing negative feedback and increasing GnRH pulsatility, which stimulates LH and FSH release for endogenous testosterone production.

Key facts

  • Molecular weight: 598.09 Da
  • Half-life: 10-14 hours
  • Bioavailability: ~50% oral
  • Storage: Room temperature, protect from moisture.

Dosing overview

  • Typical dose: 12.5-25 mg
  • Frequency: Daily
  • Duration: Ongoing or cycled 8-12 weeks
  • Route: Oral capsule

Protocol notes

  • Most start at 12.5 mg daily and adjust based on follow-up bloodwork (testosterone, LH, FSH, estradiol).
  • 25 mg daily is a common maintenance dose; higher is rarely needed and raises side-effect risk.
  • Used either continuously for testosterone optimization or as a post-cycle/restart protocol for 8-12 weeks.

Reported benefits

  • Increased endogenous testosterone
  • Preserved fertility
  • Improved libido
  • Enhanced energy and mood
  • No testicular atrophy

Possible side effects

  • Headache
  • Mood changes
  • Visual disturbances (rare)
  • Hot flashes
  • Acne

Research

  • Enclomiphene for male hypogonadism (2022): Increased testosterone to eugonadal levels in 86% of men while maintaining sperm counts above baseline.
  • Enclomiphene vs TRT comparison study (2021): Achieved comparable testosterone levels to TRT with preserved gonadotropin levels and spermatogenesis.

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Research and educational reference only. Not medical advice.