Follistatin 344 (Follistatin 344 (FST-344))
A naturally occurring glycoprotein that binds and neutralizes myostatin and activin. The longest isoform enabling significant muscle hypertrophy by removing growth inhibitors.
How it works
Binds myostatin and activin A with high affinity, preventing ActRIIB receptor activation. Removes the brake on muscle growth allowing uninhibited satellite cell proliferation.
Key facts
- Molecular weight: 36,000 Da
- Half-life: 2-4 hours
- Bioavailability: Moderate (SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 7 days.
Dosing overview
- Typical dose: 100-200 mcg
- Frequency: Daily for 10-30 days
- Duration: 10-30 day protocols
- Route: Subcutaneous
Reported benefits
- Significant muscle growth
- Myostatin inhibition
- Increased strength
- Activin neutralization
- Enhanced recovery
Possible side effects
- Limited safety data
- Theoretical reproductive effects
- Joint stress from rapid gains
- Cardiac muscle effects (theoretical)
Research
- Follistatin gene therapy for muscle wasting (2022): AAV-delivered FST-344 increased quadriceps volume by 15% in Becker MD patients.
- Myostatin inhibition by follistatin in primates (2020): Increased lean muscle by 20% without significant off-target effects over 8 weeks.
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Research and educational reference only. Not medical advice.