P21 (P21 (CNTF-Derived Tetrapeptide))
A CNTF-derived peptide promoting neurogenesis that crosses BBB. Stimulates hippocampal neurogenesis without CNTF appetite-suppressing effects.
How it works
Mimics CNTF neurogenesis-enhancing portion by increasing BDNF and activating PI3K/Akt. Inhibits LIF signaling to selectively promote neural stem cell proliferation.
Key facts
- Molecular weight: ~450 Da
- Half-life: 4-6 hours
- Bioavailability: Moderate (crosses BBB)
- Storage: Lyophilized: -20°C.
Dosing overview
- Typical dose: 50-100 mcg/kg
- Frequency: Daily
- Duration: 4-8 weeks
- Route: Intranasal or Subcutaneous
Reported benefits
- Hippocampal neurogenesis
- BDNF increase
- Cognitive enhancement
- BBB penetrant
- No appetite suppression
- Dendritic branching
Possible side effects
- Limited safety data
- Nasal irritation
- Mild headache
Research
- P21 enhances hippocampal neurogenesis and cognition (2021): Increased progenitor proliferation by 150% and improved water maze performance by 40% in aged rats.
- CNTF-derived P21 for AD prevention (2022): Prevented tau hyperphosphorylation and synaptic loss in transgenic AD mice.
Compare P21
Community discussions about P21
- Trying P21 for a cognitive boost – what have you noticed? - 4 comments
- P21 CNTF-derived peptide for neurogenesis, anyone following the BDNF angle - 4 comments
- KLOW plus P21 timing question for recovery and focus overlap - 4 comments
- P21 peptide: CNTF_codified neurogenesis and my own curiosity - 8 comments
- P21 vs Adamax for daily focus, anyone tried both? - 7 comments
- Ask the community about P21
Research and educational reference only. Not medical advice.