Alpha-Lipoic Acid (ALA) vs Glutathione
A side-by-side research comparison of Alpha-Lipoic Acid (ALA) and Glutathione across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Alpha-Lipoic Acid (ALA) | Glutathione |
|---|---|---|
| Full name | R-Alpha-Lipoic Acid Injectable | L-Glutathione (Reduced) |
| Category | Anti-Aging | Anti-Aging |
| Status | Supplement / Compounded injectable | Supplement / Injectable |
| Mechanism | Regenerates glutathione, vitamin C, and vitamin E. Chelates heavy metals. Acts as cofactor for mitochondrial enzyme complexes. Activates Nrf2 pathway for endogenous antioxidant production. | Directly neutralizes free radicals, regenerates vitamins C and E, supports phase II liver detoxification, maintains cellular redox balance, and protects mitochondrial DNA. |
| Molecular weight | 206.33 Da | 307.32 Da |
| Half-life | ~30 minutes (oral); longer IM | ~1.5-2 hours (IV/IM) |
| Bioavailability | ~30% oral; ~100% injectable | ~95% injectable; low oral (~3%) |
| Typical dose | 200-600 mg | 200-600 mg |
| Frequency | 1-3x per week (injectable) | 1-3x per week |
| Route | IV/IM injection or oral capsule | IV push, IM injection, or nebulized |
Alpha-Lipoic Acid (ALA) reported benefits
- Universal antioxidant
- Neuropathy relief
- Heavy metal chelation
- Blood sugar regulation
- Glutathione recycling
- Liver protection
Glutathione reported benefits
- Powerful antioxidant protection
- Liver detoxification support
- Skin brightening
- Immune system support
- Anti-aging cellular protection
- Heavy metal chelation
Related comparisons
Research and educational reference only. Not medical advice.