Bergamot Extract vs Nattokinase
A side-by-side research comparison of Bergamot Extract and Nattokinase across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Bergamot Extract | Nattokinase |
|---|---|---|
| Full name | Citrus Bergamia Polyphenol Extract | Nattokinase (Subtilisin NAT) |
| Category | Cardiovascular | Cardiovascular |
| Status | Dietary supplement | Dietary supplement |
| Mechanism | Polyphenolic flavonoids (brutieridin, melitidin) inhibit HMG-CoA reductase (same target as statins). Activates AMPK for fat oxidation. Reduces PCSK9 expression. Improves LDL receptor recycling for enhanced cholesterol clearance. | Directly degrades fibrin in blood clots via proteolytic activity. Also activates endogenous tissue plasminogen activator (tPA) and suppresses plasminogen activator inhibitor-1 (PAI-1), enhancing the body's own fibrinolytic system. |
| Molecular weight | Complex polyphenol mixture | ~27,728 Da |
| Half-life | ~4-6 hours | ~8-12 hours (fibrinolytic activity) |
| Bioavailability | ~15-25% (polyphenol absorption) | Oral absorption confirmed; survives GI tract |
| Typical dose | 500-1000 mg standardized extract | 2000-4000 FU (fibrinolytic units) |
| Frequency | Daily with meals | Daily on empty stomach |
| Route | Oral capsule | Oral capsule |
Bergamot Extract reported benefits
- LDL cholesterol reduction (20-35%)
- HDL improvement
- Blood glucose stabilization
- Triglyceride reduction
- Statin alternative/adjunct
- No muscle pain side effects
Nattokinase reported benefits
- Fibrin clot dissolution
- Blood pressure reduction
- Improved blood viscosity
- Reduced DVT risk
- Atherosclerosis prevention
- Natural anticoagulant alternative
Related comparisons
Research and educational reference only. Not medical advice.