Bergamot Extract vs Serrapeptase
A side-by-side research comparison of Bergamot Extract and Serrapeptase across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Bergamot Extract | Serrapeptase |
|---|---|---|
| Full name | Citrus Bergamia Polyphenol Extract | Serrapeptase (Serratiopeptidase) |
| Category | Cardiovascular | Cardiovascular |
| Status | Dietary supplement | Dietary supplement |
| Mechanism | Polyphenolic flavonoids (brutieridin, melitidin) inhibit HMG-CoA reductase (same target as statins). Activates AMPK for fat oxidation. Reduces PCSK9 expression. Improves LDL receptor recycling for enhanced cholesterol clearance. | Degrades non-living tissue including fibrin, blood clots, mucus, and arterial plaque without harming living cells. Inhibits bradykinin release and reduces prostaglandin synthesis for anti-inflammatory effects. |
| Molecular weight | Complex polyphenol mixture | ~52,000 Da |
| Half-life | ~4-6 hours | ~4-6 hours |
| Bioavailability | ~15-25% (polyphenol absorption) | Oral (enteric-coated required); detectable in bloodstream |
| Typical dose | 500-1000 mg standardized extract | 120,000-240,000 SPU |
| Frequency | Daily with meals | Daily on empty stomach |
| Route | Oral capsule | Oral (enteric-coated) |
Bergamot Extract reported benefits
- LDL cholesterol reduction (20-35%)
- HDL improvement
- Blood glucose stabilization
- Triglyceride reduction
- Statin alternative/adjunct
- No muscle pain side effects
Serrapeptase reported benefits
- Reduced inflammation and swelling
- Arterial plaque modulation
- Mucus/biofilm breakdown
- Post-surgical recovery
- Sinus/respiratory clearing
- Pain reduction
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Research and educational reference only. Not medical advice.