HCG vs Liothyronine (T3)
A side-by-side research comparison of HCG and Liothyronine (T3) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | HCG | Liothyronine (T3) |
|---|---|---|
| Full name | Human Chorionic Gonadotropin | Liothyronine Sodium (Cytomel) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA Approved | Prescription medication |
| Mechanism | Binds LH/CG receptors on Leydig cells, stimulating intratesticular testosterone synthesis and maintaining spermatogenesis via local paracrine signaling independent of pituitary FSH/LH. | Binds nuclear thyroid receptors to regulate gene transcription for basal metabolic rate, thermogenesis, protein synthesis, and carbohydrate/fat metabolism in virtually every tissue. |
| Molecular weight | ~36,700 Da | 650.97 Da |
| Half-life | ~33 hours | ~2.5 days |
| Bioavailability | ~100% (subcutaneous/intramuscular) | ~95% oral |
| Typical dose | 500-1000 IU | 5-25 mcg |
| Frequency | 2-3x per week | Daily (split AM/PM) |
| Route | Subcutaneous injection | Oral tablet or sustained-release capsule |
HCG reported benefits
- Preserved testicular size
- Maintained fertility on TRT
- Intratesticular testosterone
- Improved mood (neurosteroid support)
- Pregnenolone/DHEA maintenance
Liothyronine (T3) reported benefits
- Metabolic rate increase
- Weight loss support
- Improved energy
- Better mood
- Reduced brain fog
- Enhanced fat oxidation
Related comparisons
Research and educational reference only. Not medical advice.