DHEA vs HCG
A side-by-side research comparison of DHEA and HCG across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DHEA | HCG |
|---|---|---|
| Full name | Dehydroepiandrosterone | Human Chorionic Gonadotropin |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | FDA Approved |
| Mechanism | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. | Binds LH/CG receptors on Leydig cells, stimulating intratesticular testosterone synthesis and maintaining spermatogenesis via local paracrine signaling independent of pituitary FSH/LH. |
| Molecular weight | 288.42 Da | ~36,700 Da |
| Half-life | 15-38 hours | ~33 hours |
| Bioavailability | ~100% oral | ~100% (subcutaneous/intramuscular) |
| Typical dose | 25-100 mg | 500-1000 IU |
| Frequency | Daily (morning) | 2-3x per week |
| Route | Oral capsule or topical cream | Subcutaneous injection |
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
HCG reported benefits
- Preserved testicular size
- Maintained fertility on TRT
- Intratesticular testosterone
- Improved mood (neurosteroid support)
- Pregnenolone/DHEA maintenance
Related comparisons
Research and educational reference only. Not medical advice.