HCG (Human Chorionic Gonadotropin)
A glycoprotein hormone that mimics luteinizing hormone (LH) to maintain testicular function during TRT. Preserves fertility, intratesticular testosterone production, and prevents testicular atrophy.
How it works
Binds LH/CG receptors on Leydig cells, stimulating intratesticular testosterone synthesis and maintaining spermatogenesis via local paracrine signaling independent of pituitary FSH/LH.
Key facts
- Molecular weight: ~36,700 Da
- Half-life: ~33 hours
- Bioavailability: ~100% (subcutaneous/intramuscular)
- Storage: Lyophilized: 2-8°C. Reconstituted: refrigerate, use within 30 days.
Dosing overview
- Typical dose: 500-1000 IU
- Frequency: 2-3x per week
- Duration: Ongoing with TRT
- Route: Subcutaneous injection
Reported benefits
- Preserved testicular size
- Maintained fertility on TRT
- Intratesticular testosterone
- Improved mood (neurosteroid support)
- Pregnenolone/DHEA maintenance
Possible side effects
- Estradiol elevation
- Water retention
- Gynecomastia risk
- Desensitization at high doses
- Injection site discomfort
Research
- HCG co-administration during TRT (2019): Maintained intratesticular testosterone at 25% of baseline vs <5% in TRT-only group, preserving spermatogenesis.
- HCG for male fertility preservation (2021): Combined HCG+FSH recovered sperm parameters in 67% of TRT-induced azoospermic men within 6 months.
Compare HCG
Community discussions about HCG
- HCG + Letrozole combo for TRT‑induced estrogen spikes – need timing tips - 4 comments
- Confused about HCG dosing for beginners - 5 comments
- HCG reconstitution math is confusing me, can someone double check? - 4 comments
- How do I reconstitute HCG safely for the first time? - 4 comments
- Buy peptides online in Australia (WhatsAPP : +(61) 420-125635 ) Buy peptides online (WhatsAPP : +(61) 420-125635) Buy Peptides Online (WhatsAPP : +(61) 420-125635 ) - 3 comments
- Ask the community about HCG
Research and educational reference only. Not medical advice.