HCG vs Testosterone Cypionate
A side-by-side research comparison of HCG and Testosterone Cypionate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | HCG | Testosterone Cypionate |
|---|---|---|
| Full name | Human Chorionic Gonadotropin | Testosterone Cypionate (Depo-Testosterone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA Approved | FDA Approved (Schedule III) |
| Mechanism | Binds LH/CG receptors on Leydig cells, stimulating intratesticular testosterone synthesis and maintaining spermatogenesis via local paracrine signaling independent of pituitary FSH/LH. | Exogenous testosterone binds androgen receptors in muscle, bone, brain, and reproductive tissues. The cypionate ester provides slow release from the injection depot, maintaining physiologic levels between doses. |
| Molecular weight | ~36,700 Da | 412.61 Da |
| Half-life | ~33 hours | ~8 days |
| Bioavailability | ~100% (subcutaneous/intramuscular) | ~100% (intramuscular) |
| Typical dose | 500-1000 IU | 100-200 mg |
| Frequency | 2-3x per week | Weekly or split biweekly |
| Route | Subcutaneous injection | Intramuscular or subcutaneous injection |
HCG reported benefits
- Preserved testicular size
- Maintained fertility on TRT
- Intratesticular testosterone
- Improved mood (neurosteroid support)
- Pregnenolone/DHEA maintenance
Testosterone Cypionate reported benefits
- Restored libido and sexual function
- Increased lean muscle mass
- Improved bone density
- Enhanced mood and cognitive clarity
- Reduced visceral fat
- Improved energy and motivation
Related comparisons
Research and educational reference only. Not medical advice.