Ibutamoren (MK-677) Oral vs MK-677 (Ibutamoren)
A side-by-side research comparison of Ibutamoren (MK-677) Oral and MK-677 (Ibutamoren) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ibutamoren (MK-677) Oral | MK-677 (Ibutamoren) |
|---|---|---|
| Full name | Ibutamoren Mesylate (MK-677) | Ibutamoren Mesylate (MK-677) |
| Category | Growth Hormone | Growth Hormone |
| Status | Research compound | Investigational |
| Mechanism | Mimics ghrelin at the GHS-R1a receptor in the pituitary and hypothalamus, stimulating sustained GH release without suppressing natural pulsatility. Also increases appetite via ghrelin pathway activation. | Acts as ghrelin mimetic at GHS-R1a receptors in hypothalamus and pituitary. Excellent oral bioavailability and 24-hour duration. |
| Molecular weight | 528.66 Da | 528.7 Da |
| Half-life | ~24 hours | 24 hours |
| Bioavailability | ~60% oral | High (oral) |
| Typical dose | 10-25 mg | 10-25 mg |
| Frequency | Once daily (evening) | Once daily |
| Route | Oral capsule or liquid | Oral (capsule/liquid) |
Ibutamoren (MK-677) Oral reported benefits
- Elevated IGF-1 levels
- Improved sleep quality
- Enhanced recovery
- Increased lean mass
- Better skin/hair
- Convenient oral dosing
MK-677 (Ibutamoren) reported benefits
- Oral administration
- Sustained 24h GH elevation
- Increased IGF-1
- Improved sleep depth
- Enhanced recovery
- Bone density support
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Research and educational reference only. Not medical advice.