Ibutamoren (MK-677) Oral vs Ipamorelin
A side-by-side research comparison of Ibutamoren (MK-677) Oral and Ipamorelin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ibutamoren (MK-677) Oral | Ipamorelin |
|---|---|---|
| Full name | Ibutamoren Mesylate (MK-677) | Ipamorelin (Selective GH Secretagogue) |
| Category | Growth Hormone | Growth Hormone |
| Status | Research compound | Research compound |
| Mechanism | Mimics ghrelin at the GHS-R1a receptor in the pituitary and hypothalamus, stimulating sustained GH release without suppressing natural pulsatility. Also increases appetite via ghrelin pathway activation. | Selectively activates GHSR on pituitary somatotrophs. Unlike GHRP-6 and hexarelin, does not significantly activate ACTH or prolactin-releasing pathways. |
| Molecular weight | 528.66 Da | 711.9 Da |
| Half-life | ~24 hours | 2 hours |
| Bioavailability | ~60% oral | High (SubQ) |
| Typical dose | 10-25 mg | 100-300 mcg |
| Frequency | Once daily (evening) | 1-3x daily |
| Route | Oral capsule or liquid | Subcutaneous injection |
Ibutamoren (MK-677) Oral reported benefits
- Elevated IGF-1 levels
- Improved sleep quality
- Enhanced recovery
- Increased lean mass
- Better skin/hair
- Convenient oral dosing
Ipamorelin reported benefits
- Clean GH release
- No cortisol or prolactin increase
- Improved sleep
- Fat loss
- Joint support
- Anti-aging benefits
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Research and educational reference only. Not medical advice.