DHEA Research Guide

Full name: Dehydroepiandrosterone

A naturally occurring hormone precursor produced by the adrenal glands. Levels decline significantly with age. Commonly prescribed by telemedicine clinics as part of hormone optimization protocols.

How DHEA Works

Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism.

Dosing Protocol

• Typical dose: 25-100 mg
• Frequency: Daily (morning)
• Duration: Ongoing with monitoring
• Route: Oral capsule or topical cream

Reported Benefits

• Hormone precursor support
• Improved energy levels
• Bone density support
• Cognitive function
• Immune enhancement
• Anti-aging

Potential Side Effects

• Acne
• Hair loss (androgenic)
• Mood changes
• Oily skin
• Hormonal imbalance if overdosed

Research Citations

1. DHEA supplementation in aging adults (2020) - Restored youthful DHEA-S levels and improved bone mineral density, lean mass, and well-being scores.
2. Neurosteroid effects of DHEA (2021) - Demonstrated neuroprotective and mood-enhancing effects through GABA-A and sigma-1 receptor modulation.

Related Hormone Replacement Compounds

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• Testosterone Cypionate - Full Profile

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