Liothyronine (T3) Research Guide

Full name: Liothyronine Sodium (Cytomel)

The active thyroid hormone prescribed by telemedicine clinics for subclinical hypothyroidism, stubborn weight loss, and metabolic optimization. T3 is the biologically active form that directly controls metabolic rate.

How Liothyronine (T3) Works

Binds nuclear thyroid receptors to regulate gene transcription for basal metabolic rate, thermogenesis, protein synthesis, and carbohydrate/fat metabolism in virtually every tissue.

Dosing Protocol

• Typical dose: 5-25 mcg
• Frequency: Daily (split AM/PM)
• Duration: Ongoing with monitoring
• Route: Oral tablet or sustained-release capsule

Reported Benefits

• Metabolic rate increase
• Weight loss support
• Improved energy
• Better mood
• Reduced brain fog
• Enhanced fat oxidation

Potential Side Effects

• Heart palpitations
• Anxiety
• Insomnia
• Sweating
• Bone loss (high doses long-term)

Research Citations

1. Low-dose T3 in metabolic optimization (2022) - Addition of 5-10mcg T3 to T4 therapy improved patient-reported energy and cognitive scores with stable TSH.

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