Melanotan II Research Guide

Full name: Melanotan II (MT-II)

A synthetic cyclic alpha-MSH analog with potent melanocortin activity. Known for tanning and sexual function effects through MC1R/MC3R/MC4R activation. Parent compound of PT-141.

How Melanotan II Works

Non-selective MCR agonist: MC1R produces tanning, MC3R/MC4R increase sexual arousal, MC4R suppresses appetite. Broader receptor activity than PT-141.

Dosing Protocol

• Typical dose: 0.25-1 mg
• Frequency: Loading: daily/EOD · then 2x weekly maintenance
• Duration: Tanning: 2-4 wk load; then maintenance
• Route: Subcutaneous injection

Reported Benefits

• Skin tanning
• Enhanced sexual function
• Appetite suppression
• UV protection (melanin)
• Libido enhancement

Potential Side Effects

• Nausea (common initially)
• Facial flushing
• Spontaneous erections
• Mole darkening (monitor)
• Fatigue
• BP increase

Research Citations

1. Melanotan II effects on sexual function: systematic review (2020) - Improved erectile function in 85% and increased desire in both sexes in controlled studies.
2. Safety concerns with unregulated melanotan use (2022) - Long-term use associated with new nevi formation; dermatological monitoring recommended.

Related Sexual Health Compounds

• PT-141 (Bremelanotide) - Full Profile
• Kisspeptin-10 - Full Profile
• Oxytocin - Full Profile
• Tadalafil Peptide - Full Profile
• TriMix - Full Profile
• Tadalafil - Full Profile

View full Melanotan II profile with 3D molecule viewer →