Tadalafil Research Guide

Full name: Tadalafil (Cialis)

A long-acting PDE5 inhibitor prescribed by telemedicine clinics for erectile dysfunction and daily low-dose cardiovascular/prostate health. Its 36-hour duration of effect earned it the nickname "the weekend pill." Also used for pulmonary hypertension and BPH.

How Tadalafil Works

Selectively inhibits phosphodiesterase type 5 (PDE5), preventing cGMP breakdown in smooth muscle. This enhances nitric oxide signaling for vasodilation in penile, pulmonary, and prostate tissue.

Dosing Protocol

• Typical dose: 2.5-5 mg daily or 10-20 mg as needed
• Frequency: Daily or on-demand
• Duration: Ongoing
• Route: Oral tablet

Reported Benefits

• Erectile function improvement
• Cardiovascular health (vasodilation)
• Prostate health (BPH)
• Improved exercise capacity
• Nitric oxide support

Potential Side Effects

• Headache
• Back pain
• Muscle aches
• Nasal congestion
• Flushing
• Indigestion

Research Citations

1. Daily tadalafil and endothelial function (2022) - Daily 5mg tadalafil improved flow-mediated dilation by 30% and reduced arterial stiffness in men over 12 weeks.

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