Omega-3 (EPA/DHA) Research Guide

Full name: Omega-3 Fatty Acids (EPA + DHA)

Essential polyunsaturated fatty acids that form the backbone of anti-inflammatory signaling. EPA and DHA reduce triglycerides, stabilize cardiac rhythm, reduce platelet aggregation, and resolve chronic inflammation through specialized pro-resolving mediators (SPMs).

How Omega-3 (EPA/DHA) Works

EPA/DHA incorporate into cell membranes, displacing arachidonic acid and reducing pro-inflammatory eicosanoid production. Generate resolvins and protectins for active inflammation resolution. Activate PPARγ and inhibit NF-κB.

Dosing Protocol

• Typical dose: 2-4g combined EPA+DHA
• Frequency: Daily with meals
• Duration: Ongoing
• Route: Oral (softgel, liquid)

Reported Benefits

• Triglyceride reduction (25-45%)
• Anti-inflammatory (SPM production)
• Cardiac rhythm stabilization
• Brain and cognitive support
• Joint inflammation reduction
• Membrane fluidity optimization

Potential Side Effects

• Fishy aftertaste/burping
• Mild GI discomfort
• Increased bleeding time
• Rare: LDL elevation (DHA)

Research Citations

1. REDUCE-IT: Icosapent ethyl and CV events (2019) - High-dose EPA (4g/day) reduced cardiovascular events by 25% in statin-treated patients with elevated triglycerides.
2. Omega-3 and inflammation resolution (2021) - 3g/day EPA+DHA increased specialized pro-resolving mediators (resolvins) by 3-fold, accelerating inflammation resolution.

Related Cardiovascular Compounds

• Nattokinase - Full Profile
• Serrapeptase - Full Profile
• CoQ10 - Full Profile
• Bergamot Extract - Full Profile
• Telmisartan - Full Profile
• Vesugen - Full Profile

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