Serrapeptase (Serrapeptase (Serratiopeptidase))
A proteolytic enzyme originally isolated from Serratia bacteria in silkworm intestines. Used for its anti-inflammatory, fibrinolytic, and mucolytic properties. Popular for arterial plaque reduction and post-surgical swelling.
How it works
Degrades non-living tissue including fibrin, blood clots, mucus, and arterial plaque without harming living cells. Inhibits bradykinin release and reduces prostaglandin synthesis for anti-inflammatory effects.
Key facts
- Molecular weight: ~52,000 Da
- Half-life: ~4-6 hours
- Bioavailability: Oral (enteric-coated required); detectable in bloodstream
- Storage: Room temperature. Keep dry.
Dosing overview
- Typical dose: 120,000-240,000 SPU
- Frequency: Daily on empty stomach
- Duration: Ongoing or 8-12 week cycles
- Route: Oral (enteric-coated)
Reported benefits
- Reduced inflammation and swelling
- Arterial plaque modulation
- Mucus/biofilm breakdown
- Post-surgical recovery
- Sinus/respiratory clearing
- Pain reduction
Possible side effects
- Nausea (if taken with food)
- Rare: skin rash
- Potential bleeding risk
- GI discomfort
Research
- Serrapeptase and post-operative swelling (2020): Reduced post-surgical edema by 50% and pain scores by 40% vs placebo in dental and orthopedic procedures.
- Serrapeptase and arterial plaque (2021): Animal models showed 30% reduction in atherosclerotic plaque burden over 12 weeks with no adverse effects on healthy tissue.
Compare Serrapeptase
Community discussions about Serrapeptase
- Nausea and stomach cramps when I took Serrapeptase on a non‑empty stomach - 4 comments
- Seeking feedback on a TB‑500 plusమ fragments stack for post‑ACL rehab - 6 comments
- Serrapeptase and Mild GI/Allergic Rash – any bleeding concerns? - 6 comments
- Bleeding risk with Serrapeptase plus aspirin: personal query - 11 comments
- Adding Serrapeptase to my Wolverine stack – dosing timing and safety? - 8 comments
- Ask the community about Serrapeptase
Research and educational reference only. Not medical advice.