Serrapeptase Research Guide

Full name: Serrapeptase (Serratiopeptidase)

A proteolytic enzyme originally isolated from Serratia bacteria in silkworm intestines. Used for its anti-inflammatory, fibrinolytic, and mucolytic properties. Popular for arterial plaque reduction and post-surgical swelling.

How Serrapeptase Works

Degrades non-living tissue including fibrin, blood clots, mucus, and arterial plaque without harming living cells. Inhibits bradykinin release and reduces prostaglandin synthesis for anti-inflammatory effects.

Dosing Protocol

• Typical dose: 120,000-240,000 SPU
• Frequency: Daily on empty stomach
• Duration: Ongoing or 8-12 week cycles
• Route: Oral (enteric-coated)

Reported Benefits

• Reduced inflammation and swelling
• Arterial plaque modulation
• Mucus/biofilm breakdown
• Post-surgical recovery
• Sinus/respiratory clearing
• Pain reduction

Potential Side Effects

• Nausea (if taken with food)
• Rare: skin rash
• Potential bleeding risk
• GI discomfort

Research Citations

1. Serrapeptase and post-operative swelling (2020) - Reduced post-surgical edema by 50% and pain scores by 40% vs placebo in dental and orthopedic procedures.
2. Serrapeptase and arterial plaque (2021) - Animal models showed 30% reduction in atherosclerotic plaque burden over 12 weeks with no adverse effects on healthy tissue.

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