Quercetin Research Guide

Full name: Quercetin (Flavonoid Senolytic)

A plant flavonoid best known in biohacking as half of the classic "fisetin/dasatinib + quercetin" senolytic protocols. Also used for its antioxidant, anti-inflammatory, antihistamine, and immune-supportive properties.

How Quercetin Works

Selectively induces apoptosis in senescent cells by inhibiting pro-survival (SCAP/BCL) pathways, especially when paired with dasatinib. Also scavenges free radicals, inhibits mast-cell histamine release, and modulates NF-kB inflammatory signaling.

Dosing Protocol

• Typical dose: 500-1000 mg per day (daily) or high-dose pulsed (senolytic)
• Frequency: Daily or intermittent
• Duration: Ongoing or pulsed
• Route: Oral capsule

Reported Benefits

• Senolytic (clears senescent cells)
• Antioxidant and anti-inflammatory
• Natural antihistamine
• Cardiovascular support
• Immune modulation
• Synergy with fisetin/dasatinib

Potential Side Effects

• GI upset at high doses
• Headache
• Tingling (very high doses)
• Drug interactions (CYP inhibition)
• Kidney caution at extreme doses

Research Citations

1. Dasatinib plus quercetin clears senescent cells (2019) - The D+Q senolytic combination reduced senescent cell burden and improved physical function in a first-in-human pilot.
2. Quercetin anti-inflammatory effects (2020) - Reduced inflammatory cytokines and oxidative stress markers across multiple human and animal studies.

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