4-HO-MET (4-Hydroxy-N-methyl-N-ethyltryptamine (metocin))
A synthetic tryptamine related to psilocin, known for a gentle, colorful and emotionally warm experience. Used mainly in research and self-experimentation contexts.
How it works
Activates serotonin 5-HT2A receptors, similar to other classic tryptamine psychedelics.
Key facts
- Molecular weight: 218.30 g/mol
- Half-life: ~2 hours
- Bioavailability: Oral
- Storage: Research/reference only.
Dosing overview
- Typical dose: Varies by individual and setting
- Frequency: Occasional
- Duration: Acute effects last 4-6 hours
- Route: Oral
Protocol notes
- Taken orally in measured doses for a gentle, colorful, emotionally warm experience.
- Used in calm settings; onset is around 30-60 minutes and effects last 4-6 hours.
Reported benefits
- Gentle, visual experience
- Related to psilocin
- Studied as a research psychedelic
- Lower body load reported
Possible side effects
- Anxiety or fear
- Nausea
- Raised heart rate
- Limited human safety data
Community reviews of 4-HO-MET
- rational_coldplunge758 rated it 4/5 - Better mental clarity for my CrossFit planning: For me, the biggest change was how it cleared my head to organize my athletes' programs. It felt more or less like a gentle lift in mood without the heavy body load, no? Just my own experience, but it made my focus very sharp for a few hours ⚡.
- restlessdiego rated it 5/5 - Much lighter on the system than psilocin: My biggest win was the lower body load. Since I am always on my feet as a therapist, I cannot handle heavy physical fatigue. For me, this felt much gentler on my muscles (which is a beauty), fwiw. It just seemed to provide a cleaner, visual experience without the exhaustion 📋.
Compare 4-HO-MET
Research and educational reference only. Not medical advice.