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Cortagen (Cortagen (Brain Cortex Peptide))

Category: Cognitive & Nootropic. Status: Research compound.

A synthetic tetrapeptide bioregulator derived from brain cortex that modulates cerebral cortex function. Part of the Khavinson peptide bioregulator family.

How it works

Regulates gene expression in cerebral cortex neurons, modulating neurotransmitter receptor density, synaptic plasticity, and neuronal energy metabolism.

Key facts

  • Molecular weight: ~420 Da
  • Half-life: ~2-4 hours
  • Bioavailability: ~70% oral (as capsule); ~85% subcutaneous
  • Storage: Room temperature, sealed container.

Dosing overview

  • Typical dose: 10 mg
  • Frequency: Daily for 10-15 days
  • Duration: 10-15 day cycles, 2-3x/year
  • Route: Oral capsule or subcutaneous injection

Protocol notes

  • Run as a short bioregulator course: ~10 mg daily for 10-15 days.
  • Oral capsule is the convenient route; subcutaneous injection is used for higher bioavailability.
  • Repeat the course 2-3 times per year rather than dosing continuously.

Reported benefits

  • Cerebral cortex optimization
  • Cognitive function improvement
  • Memory enhancement
  • Neuroprotection

Possible side effects

  • Mild headache initially
  • Drowsiness (rare)
  • Vivid dreams

Research

  • Cortagen in age-related cognitive decline (2019): Improved cognitive test scores by 20% and normalized EEG patterns in elderly patients over 10-day course.
  • Peptide bioregulators for brain function (2020): Demonstrated restoration of age-declined neurotransmitter receptor density after 2-week administration.

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Research and educational reference only. Not medical advice.