Fisetin (Fisetin (Senolytic Flavonoid))
A plant flavonoid found in strawberries, apples, and onions, studied as a senolytic - an agent that selectively clears senescent ("zombie") cells that accumulate with age and drive inflammation.
How it works
Acts as a senolytic by tipping senescent cells toward apoptosis (programmed death) while sparing healthy cells. Also has antioxidant and anti-inflammatory activity.
Key facts
- Molecular weight: 286.24 Da
- Half-life: Short; poor baseline absorption (often taken with fat)
- Bioavailability: Low oral; improved with lipids/liposomal forms
- Storage: Keep cool, dry, and sealed; protect from light.
Dosing overview
- Typical dose: ~20 mg/kg on hit days (protocol-dependent)
- Frequency: Intermittent "hit and run" courses
- Duration: 2-3 consecutive days, repeated periodically
- Route: Oral
Protocol notes
- A common longevity protocol uses high-dose "hit days" (e.g. 2-3 consecutive days) every few weeks or months, rather than daily use.
- Often taken with a fatty meal or in a liposomal form to improve absorption.
- Lower daily maintenance doses are also used for general antioxidant support.
Reported benefits
- Senolytic (clears senescent cells)
- Antioxidant and anti-inflammatory
- Studied for healthspan extension
- Neuroprotective signals in research
Possible side effects
- Generally well tolerated
- Mild GI upset at high doses
- Long-term human senolytic data limited
Research
- Fisetin as a senotherapeutic (2018): Reduced senescent cell burden and extended healthspan/lifespan in aged mice.
Community reviews of Fisetin
- growth_factor_gabe rated it 5/5 - Noticed clear benefits within weeks: Added Fisetin to my protocol about 2 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- peptide_sarah rated it 5/5 - Worth adding to the protocol: Fisetin has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- research_marcus rated it 4/5 - Genuinely effective after 6 months: Been using Fisetin for about 6 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
Compare Fisetin
Community discussions about Fisetin
- Adding Quercetin to my Weekly Rapamycin – Thoughts on Timing and Dose? - 8 comments
- Fisetin Senolytic Cycling: How Long Does It Take for Effects to Show? - 6 comments
- Ask the community about Fisetin
Research and educational reference only. Not medical advice.