DHEA vs Oxandrolone
A side-by-side research comparison of DHEA and Oxandrolone across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DHEA | Oxandrolone |
|---|---|---|
| Full name | Dehydroepiandrosterone | Oxandrolone (Anavar) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | FDA Approved (Schedule III) |
| Mechanism | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. | Binds androgen receptors with high anabolic:androgenic ratio (~10:1). Does not aromatize to estrogen. Increases nitrogen retention, protein synthesis, and phosphocreatine resynthesis while reducing SHBG. |
| Molecular weight | 288.42 Da | 306.44 Da |
| Half-life | 15-38 hours | ~9 hours |
| Bioavailability | ~100% oral | ~97% oral |
| Typical dose | 25-100 mg | 10-20 mg (therapeutic); 20-50 mg (performance) |
| Frequency | Daily (morning) | Split 2x daily |
| Route | Oral capsule or topical cream | Oral |
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
Oxandrolone reported benefits
- Lean muscle gain without water retention
- Increased strength
- Fat loss (visceral)
- Wound healing acceleration
- Minimal estrogenic effects
- Improved bone density
Related comparisons
Research and educational reference only. Not medical advice.