DHEA vs Testosterone Cypionate
A side-by-side research comparison of DHEA and Testosterone Cypionate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DHEA | Testosterone Cypionate |
|---|---|---|
| Full name | Dehydroepiandrosterone | Testosterone Cypionate (Depo-Testosterone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | FDA Approved (Schedule III) |
| Mechanism | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. | Exogenous testosterone binds androgen receptors in muscle, bone, brain, and reproductive tissues. The cypionate ester provides slow release from the injection depot, maintaining physiologic levels between doses. |
| Molecular weight | 288.42 Da | 412.61 Da |
| Half-life | 15-38 hours | ~8 days |
| Bioavailability | ~100% oral | ~100% (intramuscular) |
| Typical dose | 25-100 mg | 100-200 mg |
| Frequency | Daily (morning) | Weekly or split biweekly |
| Route | Oral capsule or topical cream | Intramuscular or subcutaneous injection |
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
Testosterone Cypionate reported benefits
- Restored libido and sexual function
- Increased lean muscle mass
- Improved bone density
- Enhanced mood and cognitive clarity
- Reduced visceral fat
- Improved energy and motivation
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Research and educational reference only. Not medical advice.