DHEA vs Liothyronine (T3)
A side-by-side research comparison of DHEA and Liothyronine (T3) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DHEA | Liothyronine (T3) |
|---|---|---|
| Full name | Dehydroepiandrosterone | Liothyronine Sodium (Cytomel) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | Prescription medication |
| Mechanism | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. | Binds nuclear thyroid receptors to regulate gene transcription for basal metabolic rate, thermogenesis, protein synthesis, and carbohydrate/fat metabolism in virtually every tissue. |
| Molecular weight | 288.42 Da | 650.97 Da |
| Half-life | 15-38 hours | ~2.5 days |
| Bioavailability | ~100% oral | ~95% oral |
| Typical dose | 25-100 mg | 5-25 mcg |
| Frequency | Daily (morning) | Daily (split AM/PM) |
| Route | Oral capsule or topical cream | Oral tablet or sustained-release capsule |
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
Liothyronine (T3) reported benefits
- Metabolic rate increase
- Weight loss support
- Improved energy
- Better mood
- Reduced brain fog
- Enhanced fat oxidation
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Research and educational reference only. Not medical advice.