GlyNAC vs SS-31 (Elamipretide)
A side-by-side research comparison of GlyNAC and SS-31 (Elamipretide) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GlyNAC | SS-31 (Elamipretide) |
|---|---|---|
| Full name | Glycine + N-Acetylcysteine | SS-31 / Elamipretide (Bendavia) |
| Category | Anti-Aging | Anti-Aging |
| Status | OTC supplement combination | Investigational |
| Mechanism | Glycine and NAC (a cysteine donor) are the rate-limiting precursors for glutathione. Replenishing both restores intracellular glutathione, lowers oxidative stress, improves mitochondrial fuel oxidation, and reduces inflammation and insulin resistance. | Targets cardiolipin in inner mitochondrial membrane, stabilizes cytochrome c binding, optimizes electron transfer efficiency, and reduces mitochondrial ROS by 50%. |
| Molecular weight | Glycine 75.07 Da / NAC 163.19 Da | 640.8 Da |
| Half-life | Glycine ~1 h; NAC ~6 h | 4-6 hours |
| Bioavailability | Glycine high; NAC ~4-10% but effective as cysteine donor | High (SubQ) |
| Typical dose | Glycine ~100 mg/kg + NAC ~100 mg/kg per day | 5-40 mg |
| Frequency | Split 1-2x daily | Daily |
| Route | Oral (powder or capsule) | Subcutaneous or IV |
GlyNAC reported benefits
- Restores glutathione levels
- Improves mitochondrial function
- Lowers oxidative stress and inflammation
- Better insulin sensitivity
- Improved strength and cognition (elderly)
- Sleep support (glycine)
SS-31 (Elamipretide) reported benefits
- Mitochondrial function optimization
- Reduced oxidative stress
- Cardioprotection
- Improved exercise capacity
- Renal protection
- Cellular energy
Related comparisons
Research and educational reference only. Not medical advice.