GlyNAC vs NAD+
A side-by-side research comparison of GlyNAC and NAD+ across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GlyNAC | NAD+ |
|---|---|---|
| Full name | Glycine + N-Acetylcysteine | Nicotinamide Adenine Dinucleotide (NAD+ / NMN / NR) |
| Category | Anti-Aging | Anti-Aging |
| Status | OTC supplement combination | Research compound |
| Mechanism | Glycine and NAC (a cysteine donor) are the rate-limiting precursors for glutathione. Replenishing both restores intracellular glutathione, lowers oxidative stress, improves mitochondrial fuel oxidation, and reduces inflammation and insulin resistance. | NAD+ serves as cofactor for sirtuins (SIRT1-7), PARPs (DNA repair), and CD38. Declining NAD+ impairs mitochondrial function and epigenetic maintenance. Restoration reactivates longevity pathways. |
| Molecular weight | Glycine 75.07 Da / NAC 163.19 Da | 663.4 Da |
| Half-life | Glycine ~1 h; NAC ~6 h | 1-4 hours (IV), 4-8h (oral precursors) |
| Bioavailability | Glycine high; NAC ~4-10% but effective as cysteine donor | 100% (IV), variable (oral 5-30%) |
| Typical dose | Glycine ~100 mg/kg + NAC ~100 mg/kg per day | 250-500mg IV or 500-1000mg NMN oral |
| Frequency | Split 1-2x daily | Weekly (IV) or Daily (oral) |
| Route | Oral (powder or capsule) | IV infusion or Oral (precursors) |
GlyNAC reported benefits
- Restores glutathione levels
- Improves mitochondrial function
- Lowers oxidative stress and inflammation
- Better insulin sensitivity
- Improved strength and cognition (elderly)
- Sleep support (glycine)
NAD+ reported benefits
- Restored cellular energy
- Enhanced DNA repair
- Sirtuin activation
- Improved mitochondrial function
- Cognitive clarity
- Anti-aging
Related comparisons
Research and educational reference only. Not medical advice.