GlyNAC vs Humanin
A side-by-side research comparison of GlyNAC and Humanin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GlyNAC | Humanin |
|---|---|---|
| Full name | Glycine + N-Acetylcysteine | Humanin (HN) Mitochondrial-Derived Peptide |
| Category | Anti-Aging | Anti-Aging |
| Status | OTC supplement combination | Research compound |
| Mechanism | Glycine and NAC (a cysteine donor) are the rate-limiting precursors for glutathione. Replenishing both restores intracellular glutathione, lowers oxidative stress, improves mitochondrial fuel oxidation, and reduces inflammation and insulin resistance. | Binds IGFBP-3, BAX, and trimeric receptor (CNTFR/WSX-1/gp130) to activate STAT3. Inhibits mitochondrial apoptosis and provides neuroprotection. |
| Molecular weight | Glycine 75.07 Da / NAC 163.19 Da | 2,687 Da |
| Half-life | Glycine ~1 h; NAC ~6 h | 4-6 hours |
| Bioavailability | Glycine high; NAC ~4-10% but effective as cysteine donor | Moderate (SubQ) |
| Typical dose | Glycine ~100 mg/kg + NAC ~100 mg/kg per day | 1-5 mg |
| Frequency | Split 1-2x daily | 3-5x per week |
| Route | Oral (powder or capsule) | Subcutaneous |
GlyNAC reported benefits
- Restores glutathione levels
- Improves mitochondrial function
- Lowers oxidative stress and inflammation
- Better insulin sensitivity
- Improved strength and cognition (elderly)
- Sleep support (glycine)
Humanin reported benefits
- Neuroprotection against amyloid-beta
- Anti-apoptotic
- Improved insulin sensitivity
- Cardioprotection
- Cellular stress resistance
Related comparisons
Research and educational reference only. Not medical advice.