LL-37 (Cathelicidin Antimicrobial Peptide LL-37)
A human cathelicidin antimicrobial peptide with broad-spectrum activity against bacteria, viruses, and fungi. Also promotes wound healing and modulates innate immune response.
How it works
Disrupts microbial membranes, neutralizes endotoxins, recruits immune cells via chemotaxis, and promotes angiogenesis and re-epithelialization.
Key facts
- Molecular weight: 4493.33 Da
- Half-life: ~4-6 hours
- Bioavailability: Variable by route; topical and injectable
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C, use within 7 days.
Dosing overview
- Typical dose: 50-100 mcg
- Frequency: Daily
- Duration: 2-6 weeks
- Route: Topical or subcutaneous injection
Reported benefits
- Broad-spectrum antimicrobial
- Wound healing acceleration
- Biofilm disruption
- Immune system enhancement
Possible side effects
- Local irritation
- Redness at application site
- Mild inflammatory response
Research
- LL-37 in wound healing and infection control (2021): Enhanced wound closure rates and reduced bacterial colonization in chronic wound models.
- Cathelicidin peptides as innate immune modulators (2019): Demonstrated ability to shift macrophage polarization toward pro-healing M2 phenotype.
Community reviews of LL-37
- n_of_one rated it 5/5 - Genuinely effective after 3 weeks: Been using LL-37 for about 3 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- stack_logic_lisa rated it 4/5 - Noticed clear benefits within weeks: Added LL-37 to my protocol about 6 weeks ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- bloodwork_brett rated it 4/5 - Consistent improvement over 2 months: Added LL-37 to my protocol about 2 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- measured_mike rated it 4/5 - Worth adding to the protocol: LL-37 has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- travis_ironman rated it 5/5 - Finally got my skin to close up faster: LL-37 was the first thing I tried that seemed to make a stubborn little wound on my hand close up faster over about 8 weeks, which mattered a lot when I’m washing up and working all day in healthcare. Could just be my own experience, but I was impressed, honestly 📋
- practicalval rated it 5/5 - LL-37 beat the old stuff for my stubborn skin issues: I ran LL-37 for about 3 weeks while I was working long clinic days and still trying to stay ahead of little scrapes and stubborn skin spots that seem to come with being on my feet all day in the South. For me it seemed to calm things down faster than BPC-157 did for the same rough healing goal, and I preferred that. Could just be my own experience, but I noticed the change enough to keep notes on it.
Compare LL-37
Research and educational reference only. Not medical advice.