Taurine (Taurine (2-Aminoethanesulfonic Acid))
A conditionally essential amino acid concentrated in muscle, brain, heart, and blood cells. Circulating taurine declines with age, and a landmark 2023 study showed taurine supplementation extended healthspan and lifespan in multiple species, making it a core longevity supplement for biohackers.
How it works
Acts as a cytoprotective osmolyte and antioxidant, stabilizes mitochondrial function, modulates calcium signaling and GABA-A/glycine receptors, reduces inflammation, and supports bile acid conjugation. Taurine deficiency accelerates cellular senescence markers.
Key facts
- Molecular weight: 125.15 Da
- Half-life: ~1 hour (plasma)
- Bioavailability: ~90-100% oral
- Storage: Room temperature, keep dry.
Dosing overview
- Typical dose: 1-6 g per day
- Frequency: 1-3x daily
- Duration: Ongoing
- Route: Oral (powder or capsule)
Protocol notes
- Longevity users commonly take 2-3 g/day, split or as a single dose.
- Pre-workout use is popular at 1-2 g for endurance and cardiovascular support.
- Powder mixes easily in water; capsules are convenient but require several to reach gram doses.
Reported benefits
- Supports mitochondrial function
- Cardiovascular and blood pressure support
- Exercise endurance
- Antioxidant and anti-inflammatory
- Longevity/healthspan signal
- Calming/GABAergic effects
Possible side effects
- Generally very well tolerated
- Mild GI upset at high doses
- Rare loose stools
Research
- Taurine deficiency as a driver of aging (2023): Taurine supplementation increased healthy lifespan by ~10-12% in mice and improved multiple aging biomarkers across species.
- Taurine and cardiovascular health (2021): Supplementation lowered blood pressure and improved endothelial function in hypertensive subjects.
Compare Taurine
Research and educational reference only. Not medical advice.