Ca-AKG Research Guide

Full name: Calcium Alpha-Ketoglutarate

A calcium salt of alpha-ketoglutarate, a metabolite central to the Krebs cycle that declines with age. Popular in longevity circles for potential effects on biological aging markers, inflammation, and healthspan.

How Ca-AKG Works

Alpha-ketoglutarate is a key TCA-cycle intermediate and a cofactor for enzymes involved in energy metabolism, collagen synthesis, and epigenetic regulation (it influences DNA/histone demethylases). Supplementation aims to restore age-related declines.

Dosing Protocol

• Typical dose: 1-3 g per day
• Frequency: 1-2x daily
• Duration: Ongoing
• Route: Oral

Reported Benefits

• Supports cellular energy metabolism
• Studied for reduced biological-aging markers
• May lower inflammation
• Supports collagen synthesis

Potential Side Effects

• Generally well tolerated
• Mild GI upset at higher doses

Research Citations

1. Alpha-ketoglutarate and biological age markers (2021) - An observational study reported reductions in a DNA-methylation biological age measure with AKG supplementation.

Related Anti-Aging Compounds

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