Epithalon Research Guide

Full name: Epithalon (Epitalon / Epithalone)

A synthetic tetrapeptide based on pineal gland peptide epithalamin. One of few compounds shown to activate telomerase in human somatic cells.

How Epithalon Works

Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes.

Dosing Protocol

• Typical dose: 5-10 mg
• Frequency: Daily for 10-20 days
• Duration: 10-20 day courses, 2-3x per year
• Route: Subcutaneous injection

Reported Benefits

• Telomerase activation
• Telomere lengthening
• Melatonin normalization
• Improved sleep patterns
• Antioxidant enzyme upregulation
• Potential lifespan extension

Potential Side Effects

• Injection site reaction
• Drowsiness
• Altered sleep timing (initially)

Research Citations

1. Peptide regulation of telomerase in human somatic cells (2020) - Activated telomerase in fibroblasts, extending proliferative potential by 10 additional doublings.
2. Epithalon effects on melatonin and aging markers (2019) - Restored nocturnal melatonin peak in elderly and improved antioxidant status.

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