Humanin Research Guide

Full name: Humanin (HN) Mitochondrial-Derived Peptide

A 24-amino acid mitochondria-derived peptide with cytoprotective effects against Alzheimer toxicity, oxidative stress, and apoptosis. Levels decline significantly with age.

How Humanin Works

Binds IGFBP-3, BAX, and trimeric receptor (CNTFR/WSX-1/gp130) to activate STAT3. Inhibits mitochondrial apoptosis and provides neuroprotection.

Dosing Protocol

• Typical dose: 1-5 mg
• Frequency: 3-5x per week
• Duration: 8-12 weeks
• Route: Subcutaneous

Reported Benefits

• Neuroprotection against amyloid-beta
• Anti-apoptotic
• Improved insulin sensitivity
• Cardioprotection
• Cellular stress resistance

Potential Side Effects

• Injection site reactions
• Mild fatigue (initial)
• Limited human safety data

Research Citations

1. Humanin levels decline with age and correlate with cognition (2022) - Circulating humanin decreased 40% between ages 20-80, correlating with worse cognitive performance.
2. Cytoprotective mechanisms against amyloid-beta (2021) - Prevented AB-induced neuronal death by 70% through BAX inhibition and caspase-3 blockade.

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