GlyNAC Research Guide

Full name: Glycine + N-Acetylcysteine

A combination of glycine and N-acetylcysteine that supplies the precursors for glutathione synthesis. Clinical studies in older adults showed GlyNAC restored glutathione, improved mitochondrial function, and reversed multiple hallmarks of aging.

How GlyNAC Works

Glycine and NAC (a cysteine donor) are the rate-limiting precursors for glutathione. Replenishing both restores intracellular glutathione, lowers oxidative stress, improves mitochondrial fuel oxidation, and reduces inflammation and insulin resistance.

Dosing Protocol

• Typical dose: Glycine ~100 mg/kg + NAC ~100 mg/kg per day
• Frequency: Split 1-2x daily
• Duration: Ongoing
• Route: Oral (powder or capsule)

Reported Benefits

• Restores glutathione levels
• Improves mitochondrial function
• Lowers oxidative stress and inflammation
• Better insulin sensitivity
• Improved strength and cognition (elderly)
• Sleep support (glycine)

Potential Side Effects

• Mild GI upset
• Loose stools at high NAC doses
• Sulfur odor (NAC)
• Rare headache

Research Citations

1. GlyNAC reverses aging hallmarks in older adults (2022) - Corrected glutathione deficiency and improved mitochondrial function, insulin resistance, strength, and cognition in a clinical trial of older humans.
2. GlyNAC and oxidative stress (2021) - Reduced oxidative stress and inflammation markers while improving several aging biomarkers.

Related Anti-Aging Compounds

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• GDF-11 - Full Profile

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