Klotho Research Guide

Full name: Klotho Protein

A longevity-associated protein named after the Greek Fate who spins the thread of life. Higher Klotho levels are linked to slower aging, better cognition, and kidney and cardiovascular health. Studied for neuroprotection and age-related decline.

How Klotho Works

Exists in membrane-bound and soluble forms. Soluble Klotho acts as a circulating hormone that modulates FGF23 signaling, regulates phosphate/vitamin D balance, suppresses certain growth and oxidative-stress pathways, and supports synaptic and cognitive function.

Dosing Protocol

• Typical dose: No established human dose
• Frequency: Unknown
• Duration: Unknown
• Route: Injection (research)

Reported Benefits

• Associated with longevity and slower aging
• Neuroprotection and improved cognition (preclinical)
• Supports kidney and cardiovascular health
• Regulates phosphate and mineral balance

Potential Side Effects

• Human safety unknown
• No established side-effect profile
• Mineral/phosphate regulation effects are unstudied in supplementation

Research Citations

1. Klotho and cognitive enhancement (2014) - Elevating Klotho improved synaptic function and cognition in mouse models.
2. Klotho as a longevity hormone (2018) - Reviewed associations between higher Klotho and reduced age-related disease and mortality.

Related Anti-Aging Compounds

• Epithalon - Full Profile
• NAD+ - Full Profile
• Humanin - Full Profile
• FOXO4-DRI - Full Profile
• SS-31 (Elamipretide) - Full Profile
• GDF-11 - Full Profile

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