Spermidine Research Guide

Full name: Spermidine (Polyamine)

A naturally occurring polyamine found in foods like wheat germ, aged cheese, and natto. A popular longevity supplement studied for inducing autophagy - the cell's recycling and clean-up process - which declines with age.

How Spermidine Works

Induces autophagy, partly by inhibiting acetyltransferase activity and mimicking caloric restriction signaling. This promotes clearance of damaged proteins and organelles, supporting cellular renewal, cardiovascular health, and cognition.

Dosing Protocol

• Typical dose: 1-10 mg per day
• Frequency: Once daily
• Duration: Ongoing
• Route: Oral

Reported Benefits

• Induces autophagy (cellular clean-up)
• Cardiovascular support
• Cognitive and memory support (research)
• May support hair and overall longevity

Potential Side Effects

• Generally well tolerated
• Mild GI upset (uncommon)
• Long-term human data still developing

Research Citations

1. Spermidine intake and cardiovascular outcomes (2018) - Higher dietary spermidine was associated with lower blood pressure and reduced cardiovascular mortality in population data.
2. Spermidine and memory in older adults (2021) - A randomized trial explored spermidine supplementation for memory performance with modest signals.

Related Anti-Aging Compounds

• Epithalon - Full Profile
• NAD+ - Full Profile
• Humanin - Full Profile
• FOXO4-DRI - Full Profile
• SS-31 (Elamipretide) - Full Profile
• GDF-11 - Full Profile

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