Fisetin Research Guide

Full name: Fisetin (Senolytic Flavonoid)

A plant flavonoid found in strawberries, apples, and onions, studied as a senolytic - an agent that selectively clears senescent ("zombie") cells that accumulate with age and drive inflammation.

How Fisetin Works

Acts as a senolytic by tipping senescent cells toward apoptosis (programmed death) while sparing healthy cells. Also has antioxidant and anti-inflammatory activity.

Dosing Protocol

• Typical dose: ~20 mg/kg on hit days (protocol-dependent)
• Frequency: Intermittent "hit and run" courses
• Duration: 2-3 consecutive days, repeated periodically
• Route: Oral

Reported Benefits

• Senolytic (clears senescent cells)
• Antioxidant and anti-inflammatory
• Studied for healthspan extension
• Neuroprotective signals in research

Potential Side Effects

• Generally well tolerated
• Mild GI upset at high doses
• Long-term human senolytic data limited

Research Citations

1. Fisetin as a senotherapeutic (2018) - Reduced senescent cell burden and extended healthspan/lifespan in aged mice.

Related Anti-Aging Compounds

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