FGL Research Guide

Full name: FGL (NCAM-Derived Peptide)

A peptide from the FG loop of neural cell adhesion molecule (NCAM). Enhances synaptic plasticity, memory, and neurotrophic effects through FGFR activation.

How FGL Works

Mimics NCAM FG loop interacting with FGFR1 to promote LTP, neurite outgrowth, neuronal survival, and presynaptic function enhancement.

Dosing Protocol

• Typical dose: 1-5 mg/kg (research)
• Frequency: Daily or every other day
• Duration: 2-4 weeks
• Route: Subcutaneous

Reported Benefits

• Synaptic plasticity
• LTP facilitation
• Memory improvement
• Neurotrophic effects
• FGFR activation

Potential Side Effects

• Limited data
• Theoretical mitogenic concern
• Injection site reaction

Research Citations

1. FGL enhances hippocampal LTP and memory in aged rats (2020) - Restored LTP to young-adult levels and improved contextual fear memory by 45%.
2. NCAM-derived peptides for cognitive enhancement (2019) - Improved social memory and reduced anxiety through FGFR1-dependent synaptic modulation.

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