NSI-189 Research Guide

Full name: NSI-189 Phosphate (Neurogenic Compound)

A small molecule stimulating hippocampal neurogenesis. Developed for MDD, it increases hippocampal volume measurable by MRI and improves cognition independent of mood effects.

How NSI-189 Works

Stimulates hippocampal neural stem cell proliferation and differentiation via Akt/CREB/BDNF signaling. Increases hippocampal volume visible on MRI.

Dosing Protocol

• Typical dose: 40-80 mg
• Frequency: Once daily
• Duration: 8-12 weeks
• Route: Oral

Reported Benefits

• Hippocampal neurogenesis
• Measurable brain volume increase
• Cognitive enhancement
• Antidepressant effects
• Long-term neural benefit

Potential Side Effects

• Headache
• Insomnia
• Agitation
• Dizziness
• Suicidal ideation (monitor)

Research Citations

1. NSI-189 Phase 2 in MDD (2019) - Significant cognitive improvements (SDR, CogScreen) vs placebo but missed primary depression endpoint.
2. Hippocampal volume changes with NSI-189 (2020) - 4% hippocampal volume increase after 12 weeks vs 1% decrease in placebo on MRI.

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