P21 Research Guide

Full name: P21 (CNTF-Derived Tetrapeptide)

A CNTF-derived peptide promoting neurogenesis that crosses BBB. Stimulates hippocampal neurogenesis without CNTF appetite-suppressing effects.

How P21 Works

Mimics CNTF neurogenesis-enhancing portion by increasing BDNF and activating PI3K/Akt. Inhibits LIF signaling to selectively promote neural stem cell proliferation.

Dosing Protocol

• Typical dose: 50-100 mcg/kg
• Frequency: Daily
• Duration: 4-8 weeks
• Route: Intranasal or Subcutaneous

Reported Benefits

• Hippocampal neurogenesis
• BDNF increase
• Cognitive enhancement
• BBB penetrant
• No appetite suppression
• Dendritic branching

Potential Side Effects

• Limited safety data
• Nasal irritation
• Mild headache

Research Citations

1. P21 enhances hippocampal neurogenesis and cognition (2021) - Increased progenitor proliferation by 150% and improved water maze performance by 40% in aged rats.
2. CNTF-derived P21 for AD prevention (2022) - Prevented tau hyperphosphorylation and synaptic loss in transgenic AD mice.

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