Top peptides for skin repair, collagen stimulation and anti-wrinkle effects - GHK-Cu, Matrixyl, and copper peptides.
A naturally occurring copper-binding tripeptide that declines with age. Promotes collagen synthesis, wound healing, and has broad regenerative effects on skin, hair follicles, and tissues.
Dose: 1-3 mg topical ยท 200-500 mcg injectable | Route: Topical cream/serum or subcutaneous injection
A lipopeptide of palmitic acid linked to pentapeptide KTTKS. One of the most researched anti-aging cosmeceutical peptides, stimulating collagen and fibronectin.
Dose: 2-8% in serum/cream | Route: Topical
A synthetic hexapeptide that mimics SNAP-25 protein. Often called "topical Botox," it reduces expression lines by inhibiting neurotransmitter release at neuromuscular junctions.
Dose: 5-10% solution | Route: Topical
An elongated version of argireline (8 vs 6 amino acids) providing enhanced SNARE complex inhibition for superior wrinkle reduction.
Dose: 3-10% solution | Route: Topical
A family of small peptides complexed with copper ions that stimulate collagen synthesis, wound healing, and skin remodeling. Beyond GHK-Cu, includes AHK-Cu and other tripeptide-copper complexes.
Dose: 1-3% topical solution | Route: Topical
Read full Copper Peptides guide →
A pentapeptide mimicking enkephalin that binds enkephalin receptors on nerve cells, reducing neural excitability and complementing argireline for enhanced anti-wrinkle effects.
Dose: 3-5% solution | Route: Topical
A lipopeptide acting as a matrikine, signaling skin repair by mimicking collagen breakdown products that trigger fibroblast collagen production.
Dose: 2-5% in formulation | Route: Topical
Read full Palmitoyl Tripeptide-1 guide →
A lipopeptide that reduces IL-6 secretion and inflammaging. Often paired with Pal-Tripeptide-1 as "Matrixyl 3000" for combined collagen-building and anti-inflammatory action.
Dose: 2-4% in formulation | Route: Topical
Read full Palmitoyl Tetrapeptide-7 guide →
The advanced acetylated formulation of argireline with improved delivery and stability for topical anti-wrinkle applications.
Dose: 5-10% | Route: Topical
Read full Acetyl Hexapeptide-8 guide →
Bioactive peptide fragments from enzymatic hydrolysis of collagen protein. Orally bioavailable and stimulate endogenous collagen synthesis in skin, joints, and bones.
Dose: 5-15 g | Route: Oral (powder/capsule)
Read full Collagen Peptides guide →
Bioactive fragments from elastin hydrolysis that signal fibroblasts to produce tropoelastin and support the elastic fiber network for skin resilience.
Dose: 1-5% topical or 2-5g oral | Route: Topical or Oral
Read full Elastin Peptides guide →
Bioactive peptides from silk fibroin (Bombyx mori). Rich in glycine, alanine, and serine, they form moisture-retaining films while providing amino acid building blocks.
Dose: 1-5% topical or 2-5g oral | Route: Topical or Oral
Read full Silk Peptides guide →