Best Compounds for Testosterone Optimization

Research compounds for testosterone support - gonadorelin, enclomiphene, kisspeptin and hormonal optimization protocols.

Gonadorelin

A synthetic analog of gonadotropin-releasing hormone used diagnostically and therapeutically. Stimulates pulsatile LH and FSH release to maintain natural hormone production.

Dose: 100-500 mcg | Route: Subcutaneous injection

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Enclomiphene

A selective estrogen receptor modulator (SERM) and the trans-isomer of clomiphene. Widely prescribed by telemedicine clinics as a testosterone optimization therapy that maintains fertility, unlike exo

Dose: 12.5-25 mg | Route: Oral capsule

Read full Enclomiphene guide →

HCG

A glycoprotein hormone that mimics luteinizing hormone (LH) to maintain testicular function during TRT. Preserves fertility, intratesticular testosterone production, and prevents testicular atrophy.

Dose: 500-1000 IU | Route: Subcutaneous injection

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DHEA

A naturally occurring hormone precursor produced by the adrenal glands. Levels decline significantly with age. Commonly prescribed by telemedicine clinics as part of hormone optimization protocols.

Dose: 25-100 mg | Route: Oral capsule or topical cream

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Pregnenolone

The master precursor hormone from which all steroid hormones are derived. Often called the "mother hormone," it supports cognitive function, mood, and hormonal balance. Popular in telemedici

Dose: 50-100 mg | Route: Oral capsule or sublingual

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Liothyronine (T3)

The active thyroid hormone prescribed by telemedicine clinics for subclinical hypothyroidism, stubborn weight loss, and metabolic optimization. T3 is the biologically active form that directly control

Dose: 5-25 mcg | Route: Oral tablet or sustained-release capsule

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Anastrozole

An aromatase inhibitor widely prescribed by telemedicine clinics alongside testosterone therapy to control estrogen conversion. Prevents testosterone from being converted to estradiol, maintaining hor

Dose: 0.25-0.5 mg | Route: Oral tablet

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Testosterone Cypionate

The gold standard testosterone ester for hormone replacement therapy. Provides stable serum testosterone levels with weekly or biweekly injections. Prescribed for male hypogonadism and increasingly us

Dose: 100-200 mg | Route: Intramuscular or subcutaneous injection

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Progesterone

A bioidentical hormone with neuroprotective, sleep-promoting, and anti-estrogenic properties. Used in both male and female HRT protocols for mood stabilization, deep sleep enhancement, and estrogen ba

Dose: 100-200 mg oral or 20-40 mg topical | Route: Oral capsule, topical cream, or vaginal

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Kisspeptin-10 (HPG Axis)

A hypothalamic neuropeptide that is the master upstream regulator of the HPG axis. Stimulates natural GnRH pulsatility to restore endogenous testosterone, LH, and FSH production without suppressing th

Dose: 100-400 mcg | Route: Subcutaneous injection

Read full Kisspeptin-10 (HPG Axis) guide →

Clomiphene Citrate

A selective estrogen receptor modulator (SERM) used off-label in men to raise endogenous testosterone by blocking hypothalamic estrogen feedback. An alternative to TRT that preserves fertility.

Dose: 12.5-50 mg | Route: Oral

Read full Clomiphene Citrate guide →

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